Preparation and characterization of miglitol-loaded Poly (d, l-lactide-co-glycolide) microparticles using high pressure homogenization-solvent evaporation method

ABSTRACT

Sustained release Miglitol-loaded poly (d, l-lactide-co-glycolide) (PLGA) microparticles were prepared using high pressure homogenization-solvent evaporation method. 2³ full factorial design was employed to study effect of independent variables (X₁-Polymer amount; X₂-Surfactant concentration and X₃-Homogenization Pressure) on percent encapsulation efficiency (%EE) as response. The microparticles produced were characterized for particle size, morphology, % EE, drug polymer compatibility and in vitro drug release. An average particle size of Miglitol-loaded PLGA microparticles was 230.1 nm and found almost spherical with smooth surface. % EE ranged from 58.7% ± 2.11 to 86.5% ± 0.24 depending on the polymer amount, surfactant concentration and homogenization pressure. An absence of chemical interaction between drug-polymer and reduction in % crystallinity of drug was confirmed by FTIR and X-ray diffraction analysis respectively. In vitro release studies showed a sustained release of Miglitol from microparticles up to 12 hrs.

GRAPHICAL ABSTRACT

KEYWORDS:

• Microparticles
• miglitol
• PLGA
• solvent evaporation
• sustained release

Acknowledgement

Authors are very much thankful to Glenmark Pharmaceuticals, Nashik, India for providing gift sample of Miglitol (MGL) and PURAC biochem, Holland for providing gift sample of Poly (D, L-lactide-glycolide) −75:25 respectively.

Additional information

Funding

The work is supported by Department of Science and Technology (DST), New Delhi, India through grant IF131166 (DST-INSPIRE fellowship).