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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 68, 2019 - Issue 5
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Original Articles

Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering

Mehmet Onur AydogduAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey;Department of Metallurgical and Materials Engineering, Master of Science, Institute of Pure and Applied Sciences, Marmara University, Istanbul, TurkeyView further author information
,
Joshua ChouAdvanced Tissue Regeneration and Drug Delivery Group, School of Medical and Molecular Sciences, University of Technology Sydney, Sydney, NSW, AustraliaView further author information
,
Esra AltunAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey;Department of Metallurgical and Materials Engineering, Master of Science, Institute of Pure and Applied Sciences, Marmara University, Istanbul, TurkeyView further author information
,
Nazmi EkrenAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey;Department of Electrical and Electronics Engineering, Faculty of Technology, Marmara University, Istanbul, TurkeyView further author information
,
Selami CakmakOrthopedics and Traumatology Clinic, Acibadem Kadikoy Hospital, Istanbul, TurkeyView further author information
,
Mehmet ErogluDepartment of Chemical Engineering, Faculty of Engineering, Marmara University, Istanbul, TurkeyView further author information
,
Asila A. OsmanDepartment of Chemical Engineering, Faculty of Engineering, Marmara University, Istanbul, TurkeyView further author information
,
Ozlem KutluNanotechnology Research and Application Center, & (EFSUN) Center of Excellence for Functional Surfaces and Interfaces for Nano Diagnostics, Sabanci University, Istanbul, TurkeyView further author information
,
Ebru Toksoy OnerDepartment of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, TurkeyView further author information
,
Gulben AvsarDepartment of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, TurkeyView further author information
,
Faik Nuzhet OktarAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey;Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, TurkeyView further author information
,
Ismail YilmazPathology Department, Istanbul Sultan Abdulhamid Han Training Hospital, Istanbul, TurkeyView further author information
&
Oguzhan GunduzAdvanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey;Department of Metallurgical and Materials Engineering, Master of Science, Institute of Pure and Applied Sciences, Marmara University, Istanbul, TurkeyCorrespondence[email protected]
View further author information
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Pages 243-255 | Received 07 Dec 2017, Accepted 19 Feb 2018, Published online: 09 Mar 2018
 
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ABSTRACT

A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability.

GRAPHICAL ABSTRACT

Acknowledgements

This study has been founded by BAPKO, Marmara University; grant no: FEN-B-080415-0117.

In-vivo histological and pathological testing of this study were carried out under the permission of Marmara University Animal Experiments Local Ethics Committee. Protocol number: 104.2016.mar

Additional information

Funding

This work was supported by the BAPKO, Marmara University [Grant number FEN-B-080415-0117].

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