Comparative analysis of TiO₂ and Ag nanoparticles on xylan/chitosan conjugate matrix for wound healing application

Abstract

Our present study evaluates the performance of wound dressing material fabricated by incorporating silver(Ag) and titanium dioxide(TiO₂) nanoparticles(NPs) in xylan/chitosan-based conjugate matrix. The porous nanocomposites were examined for antimicrobial, cell attachment, swelling, protein adsorption, and cytotoxic studies. Nanocomposites exhibited potent antimicrobial response against both gram-negative and gram-positive strains of bacteria. Despite remarkable cellular response, a concentration-dependent cytotoxicity was observed in matrix with high Ag NPs content. Nanoparticles incorporated composites also tuned the pore size, swelling ratio, and protein adsorption tendency of scaffold making them feasible as wound dressing material.

Graphical abstract

Keywords:

• Chitosan
• silver NPs
• TiO₂ NPs
• wound healing
• xylan

Acknowledgements

The authors would like to acknowledge Ministry of Human Resource and Development, Government of India for providing financial support.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was funded by Ministry of Human Resource Development, Government of India.