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Abstract
Novel shell crosslinked (SCL) pH- and reduction-responsive micelles were fabricated through the grafting of DMAEMA and AA monomers onto a star-shaped PCL through ATRP followed by crosslinking with Cys. The chemical structures of the samples were investigated using 1H NMR and FTIR. The developed micelles were loaded with MTX as an anticancer drug and their drug loading and encapsulation efficiencies were calculated to be 31.53 ± 0.3% for both. The fabricated drug delivery system (DDS) exhibited slow and stimuli-triggered drug release behavior. The anticancer performance of the DDS was examined using MTT assay against MCF7 cells.
Graphical Abstract
Disclosure statement
The authors declare no competing financial interest.
Additional information
Funding
The authors gratefully acknowledge the partial financial support from Payame Noor University, Tehran, Iran, and Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.