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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 71, 2022 - Issue 15
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Research Article

Evaluation of angiogenic potential of heparin and thyroxine releasing wound dressings

Waliya Zubairia Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad Lahore Campus, Lahore, Pakistan;b Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, PakistanView further author information
,
Mubashra Zehraa Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad Lahore Campus, Lahore, Pakistan;c National Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, PakistanView further author information
,
Azra Mehmoodc National Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, PakistanView further author information
,
Farasat Iqbala Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad Lahore Campus, Lahore, PakistanView further author information
,
Rida Badara Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad Lahore Campus, Lahore, PakistanView further author information
,
Anwarul Hasand Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar;e Biomedical Research Center, Qatar University, Doha, QatarView further author information
&
Muhammad Yara Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad Lahore Campus, Lahore, PakistanCorrespondence[email protected]
View further author information
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Pages 1164-1175 | Received 23 Apr 2021, Accepted 22 Jul 2021, Published online: 17 Nov 2021
 
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Abstract

In the present research, heparin (1 μg/ml, 5 μg/ml) and thyroxine (1 μg/ml, 5 μg/ml) loaded wound dressings were prepared. Ultrastructure of the developed scaffolds revealed by scanning electron microscope and fourier transform infrared spectroscopy proved them an attractive choice for skin tissue engineering. Drug release kinetics showed maximum release (95%) of thyroxine by day 3 compared to the heparin having sustained release until the endpoint of the assay. The angiogenic abilities of synthesized materials were evaluated through chorioallantoic membrane (CAM) assay. Our findings demonstrate that the developed scaffolds are the promising choice for wound healing applications especially with regards to their angiogenic properties.

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Additional information

Funding

We acknowledge Higher Education Commission of Pakistan for financially supporting this research under NRPU project number 8762.

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