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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 72, 2023 - Issue 12
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Research Articles

Poly (amido amine) G5 modified mesoporous silica-based pH-responsive drug-delivery system for tetracycline and ibuprofen

Roya OmidiDepartment of Materials Science and Engineering, Tarbiat Modares University, Tehran, Iran
,
Parvin AlizadehDepartment of Materials Science and Engineering, Tarbiat Modares University, Tehran, IranCorrespondence[email protected]
&
Mohammad SoltaniDepartment of Materials Science and Engineering, Tarbiat Modares University, Tehran, Iran
Pages 984-994 | Received 11 Nov 2021, Accepted 25 Apr 2022, Published online: 06 May 2022
 
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Abstract

In this novel communication, mesoporous silica/poly (amidoamine) generation 5 nanocomposite was synthesized through 3-glycidoxypropyltrimethoxysilane (GPTMS) and its functionality was studied. Successful functionalization of mesoporous silica with PAMAM was studied through Transmission electron microscopy (TEM). N2 adsorption-desorption was indicative of a surface area of 1,321 m2/g and a mean pore diameter of 2 nm. Successful drug loading and optimal release were confirmed using Fourier transform infrared (FTIR) and ultraviolet-visible spectroscopy (UV-Vis), respectively. Furthermore, at 256 μg/mL concentration samples demonstrated antibacterial activity toward Staphylococcus aureus and Escherichia coli bacteria, and cell viability for all samples after 72 h was more than 70%.

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