Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies

Abstract

Gynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.

GRAPHICAL ABSTRACT

Keywords:

• Biodegradable polymers
• drug-delivery system
• gynecological malignancy
• nanoparticles

Additional information

Funding

This work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).