A porous Co-MOF for CO₂ conversion and protective activity on infectious fever by reducing bacterial inflammatory response

Abstract

By applying a mixed-ligand approach based on an amino functionalized ligand 1-aminobenzene-3,4,5-tricarboxylic acid (H₃abta), a novel metal-organic framework (MOF) containing Co(II) ion {[Co_2.5(abta)(trz)₂ (H₂O)]·3H₂O}_n (1, Htrz = 1H-1,2,4-triazole) were produced via Co(NO₃)₂·6H₂O reacting with H₃abta with the existence of Htrz as the co-ligand. The prepared catalyst 1a (activated 1) is abundant in the amino groups and open metal sites (OMSs), which is helpful to obtain high CO₂ capacity of adsorption around room temperature and effectively convert CO₂ to pentacyclic carbamate with the help of Bu₄NBr as the cocatalyst. For the treatment of infectious fever, the colony-forming unit (CFU) was performed and the E. coli number in the mice was counted. Next, the inflammatory cytokines level in the infected mice was measured after the compound treatment.

Graphical abstract

Keywords:

• Coordination polymer
• adsorption capacity
• infectious fever

Conflicts of interest

The authors declare that there is no conflict of interest regarding the publication of this paper.

Data availability

The data used to support the findings of this study are included within the article.