Synthesis of a magnetic SiO₂-HPW₁₂O₄₀@Fe₃O₄/EN-MIL-101(Cr) catalyst as core-shell nanoparticles and determination of losartan using modified glassy carbon electrode

Abstract

The synthesis and properties of new hybrid core-shell nanoparticles SiO₂-HPW₁₂O₄₀@Fe₃O₄/EN-MIL-101(Cr) are reported. These hybrid nanomaterials were synthesized by binding of Keggin-type heteropolyacid (HPA) on diamine-activated Fe₃O₄ magnetic nanoparticles. The present work proposes an electroanalytical method for selective determination of losartan antihypertensive drug (LOS). Under optimal conditions, an electrochemical sensor was performed between the molecules in 0.1 M phosphate buffer (PBS) pH 6.0. Heterogeneous nanocatalysts can be easily separated from the reaction mixture using a magnet and used multiple times. The structure of the synthesized nanocatalyst was determined by various physicochemical techniques such as TEM, SEM, XRD, EDAX, TGA, and AFM.

Graphical abstract

KEYWORDS:

• Metal-organic framework
• diamine-functionalized Fe₃O₄ magnetic nanoparticles
• Keggin-type heteropolyacid
• modified electrodes
• heterogeneous catalyst

Acknowledgement

We gratefully acknowledge financial support from the Research Council of the Islamic Azad University of Yazd.

Disclosure statement

No potential conflict of interest was reported by the authors.