Zn(II) complexes with a new isoniazid ligand: synthesis, structural characterization and antimycobacterial activity

Abstract

The present work reports the synthesis of two new zinc(II) complexes based on the 2-acetylfuranisonicotinichydrazone ligand (HL). The structure of the hydrazone and [ZnCl₂(HL)]·MeOH (1) and [Zn(L)₂] (2) have been elucidated by single-crystal X-ray diffraction method, physicochemical, and spectroscopic techniques. The hydrazone is a bidentate ligand, forming two new mononuclear complexes with zinc(II). Non-covalent interactions in the structures of the compounds were evaluated with Hirshfeld surface analysis, which showed the presence of hydrogen bonds in HL and 1 and also a π···π stacking interaction in 1. The antimycobacterial potentials of the compounds were tested against tuberculous and non-tuberculous mycobacteria strains.

Graphical Abstract

Keywords:

• Zinc(II) complexes
• isoniazid
• crystal structures
• antimycobacterial potential

Acknowledgments

All funding agencies are acknowledged for partial financial support.

Disclosure statement

There are no conflicts of interest to declare.

Author contributions

The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.

Additional information

Funding

The authors wish to thank the financial support of FAPDF, FINEP/CTINFRA, DPI-UnB, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) – process number 307974/2019-7.