Construction and characterization of Fe₃O₄@BAAH-CuCl nanomagnetic catalyst: catalysis research in synthesis of 2-aryl quinazolines from prepared benzylamines

Abstract

We have constructed Fe₃O₄@BAAH-CuCl nanomagnetic catalyst in ChCl-Urea (choline chloride deep eutectic as solvent) as a highly efficient catalytic system for the preparation of 2-aryl quinazoline derivatives through one-pot, three-component reactions of 2-bromobenzaldehyde with primary amines and sodium azide under molecular oxygen. FT-IR, VSM, SEM, TEM, TGA, XRD, EDX, ICP-OES and elemental mapping analyses confirmed the fabrication of Fe₃O₄@BAAH-CuCl nanomaterial. In this project, we first prepared various derivatives of benzylamines from reduction of aryl nitriles, then used the benzylamine products as substrates in the three-component synthesis of 2-aryl quinazoline derivatives in the presence of Fe₃O₄@BAAH-CuCl/ChCl-Urea as an efficient catalytic system. Although the synthesized products (primary amines and 2-aryl quinazolines) were known, their physical state was confirmed with the reported samples in the literature and the structure of all the products confirmed by ¹HNMR and ¹CNMR.

Keywords:

• Fe₃O₄@BAAH-CuCl Nonmagnetic catalyst
• ChCl-urea solvent
• benzylamines
• 2-aryl quinazoline derivatives
• ecofriendly conditions

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Khalid Mujasam Batoo is thankful to the Researchers Supporting Project Number (RSP2024R148) at King Saud University, Saudi Arabia for the financial support.