Paternal body mass index before conception associated with offspring’s birth weight in Chinese population: a prospective study

Abstract

Whether paternal epigenetic changes resulting from nutrition might be inherited by their offspring remains unknown. This study evaluated the relationship between preconception paternal body weight and their offspring’s birth weight in 1,810 Chinese mother-father-baby trios. Information on paternal and maternal preconception body weight and height was collected via a self-reported questionnaire. Birth weight was collected from medical records. Paternal preconception body weight was associated with offspring’s birth weight (p trend = .02) after multivariate adjustment. Each standard deviation increment of paternal body mass index was associated with an additional 29.6 g increase of birth weight (95% confident interval: 5.7 g, 53.5 g). The association was more pronounced in male neonates, and neonates with overweight mothers, and with mothers who gained excessive gestational weight, compared to their counterparts (all p interaction < .05). Sensitivity analyses showed similar pattern to that of the main analysis. Paternal preconception body weight was associated with birth weight of their offspring.

Impact statement

• What is already known on this subject? More efforts have previously been put on the maternal contribution to birth weight, however, it is uncertain whether paternal pre-conceptional body weight, an indicator for epigenetic information, might be inherited by their offspring.

• What do the results of this study add? In the current study that included 1,810 Chinese mother-father-baby trios, a small but significant association was observed between paternal preconception body weight and offspring’s birth weight (p trend =.02).

• What are the implications of these findings for clinical practice and/or further research? Paternal epigenetic information of nutrition could be inherited by their offspring.

Keywords:

• Birth weight
• offspring
• paternal body weight
• preconception

Disclosure statement

All the authors declared no conflict interest.

Data availability statement

The SAS code and data that support the findings of this study are available from the first author upon reasonable request (Renying Xu, email address: [email protected]).

Additional information

Funding

The study was supported by Scientific Research Starting Foundation of South Campus Ren Ji Hospital [2014QDQ10], and by the grant from Shanghai Key Laboratory of Paediatric Gastroenterology and Nutrition [No.17DZ2272000].