Pipelle endometrial sampling success rates in Kazakhstani settings: results from a prospective cohort analysis

Abstract

The aim of this study was to evaluate the feasibility of Pipelle endometrial sampling and to explore factors influencing Pipelle success rate in the clinical settings of Kazakhstan. This prospective analysis included 87 patients who had undergone Pipelle biopsy due to medical indications for endometrial sampling. We analysed physician and patient-related factors potentially influencing the success rate of this method. Pipelle endometrial biopsy overall success rate was 82.76%. The indications for the procedure and patients’ age were key factors influencing Pipelle sampling success (p < .001). The success rate was the highest in the group with abnormal uterine bleeding as a biopsy indication in the reproductive age group (93.19%; p < .001).

Pipelle biopsy was found to be an acceptable option for endometrial sampling in our clinical setting; at the same time, physicians should consider the potential influencing factors on its success rate like indications for the procedure, BMI and patients’ age as well as their menopausal status. In order to provide precise future directions, there is a need to study a larger number of patients.

IMPACT STATEMENT

• What is already known on this subject? Compared to dilation and curettage sampling conducted in the operation room, Pipelle endometrial sampling is relatively inexpensive, associated with less morbidity, safe, accurate, and can be performed in an office setting.

• What do the results of this study add? This is the first prospective data analysis about Pipelle endometrial sampling in Kazakhstani population.

• What are the implications of these findings for clinical practice and/or further research? Enabling the timely diagnosis of current endometrial pathology, Pipelle endometrial sampling approach may have an important impact on healthcare safety and efficiency, and improve overall treatment outcomes and the quality of life of Kazakhstani population if used consistently.

Keywords:

• Abnormal uterine bleeding
• dilatation and curettage
• endometrial sampling
• endometrial hyperplasia
• Pipelle biopsy

Authors’ contributions

M.T., G.B. and A.K. were responsible for conception and study design; M.T., G.B., T.U. and K.K. were responsible for the samples collection; B.I. and A.L. performed histological analysis; A.K. compiled, analysed, drafted and reviewed data; S.T., G.A. and A.S.L. provided administrative support; M.T., G.A., A.K., A.S.L., and S.T. prepared and finalised the manuscript. S.G., I.A., I.H. and G.G. edited the manuscript. All authors reviewed and approved the final manuscript.

Acknowledgements

We would like to recognize Dr. Faina Linkov, University of Pittsburgh, Pittsburgh, PA, USA. FL guided the development of the protocols for this study and IRB materials. She also helped with the preparation of the manuscript.

Disclosure statement

All Authors have no proprietary, financial, professional or other personal interest of any nature in any product, service or company.

Additional information

Funding

This study was supported by the Nazarbayev University Grant [Number 110119FD4540, 2019-2022].