Determination of acyclovir in renal microdialysis fluid and confirmation of renal function index

Abstract

Acyclovir (ACV) is a nucleoside antivirus-free agent that was developed and marketed by Burroughs Well-come of the United States. Renal damage from ACV has been a major factor limiting its clinical application. Thus, the renal toxicity mechanism of ACV requires systematic study. In our previous study, we speculated that the nephrotoxicity of ACV may be associated with oxidative stress. In addition to the study of ACV’s toxic effect in vivo, it is also necessary to explore the absorption and distribution of ACV in the body to further investigate the changes to ACV in the body. In this study, the toxicokinetics ACV in the kidney of the rat were explored using microdialysis, and the renal function of rats was measured. The results showed that high-dose ACV is associated with renal toxicity after a single intravenous injection or successive administration.

Keywords:

• Acyclovir
• nephrotoxicity
• toxicokinetics
• microdialysis
• intravenous injection

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

This work was supported by grants from the Medical Science and Technology Project of Zhejiang Province [No. 2012RCA015].