Studies on oral subacute toxicity of cartap in male mice

Abstract

S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in cabbage and cauliflower crops. Cartap, as a pesticide has not been investigated yet for its effect on vital organs and biochemical stress in vivo and the present study was undertaken to evaluate the same in Swiss albino mice. For this purpose male mice were given three different dose levels of cartap, i.e. 5 mg/kg, 7.5 mg/kg and 15 mg/kg body weight respectively, for 28 days orally. Water was used as vehicle to dissolve cartap. Oral administration of cartap caused significant increase in serum biomarkers, tissue oxidants and decrease in antioxidants along with histopathological findings in liver, kidney and brain tissues. Thus, present study showed that in vivo exposure to cartap induces tissue damage probably via oxidative stress in important vital organs of mice.

Keywords:

• Cartap
• oxidative stress
• histopathology
• liver
• kidney and brain

Acknowledgement

The junior research fellowship (JRF) awarded to the first author by the Indian Council of Agriculture Research (ICAR), Govt. of India is gratefully acknowledged. The authors are thankful to the Director, Indian Veterinary Research Institute (IVRI) for providing necessary facilities and funds. Authors express their gratitude to M/s. Cheminova Industries Ltd., Mumbai, India for supplying technical grade cartap complimentary.

Disclosure statement

Authors state no conflict of interest in this study