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Abstract
Objective: Whether to conduct Sijunzi decoction combined with enteral nutrition (SJZD/EN) in patients with gastric cancer (GC) remains controversial. This study was aimed to systematically analyze the efficacy and safety of SJZD/EN in patients with gastric cancer.
Methods: We performed searches in PubMed, MEDLINE, EMBASE, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Wanfang database, and Chinese Biomedicine Literature Database (SinoMed) to identify relevant literature comparing SJZD/EN with conventional EN for GC patients. The analysis was carried out with RevMan 5.3.
Results: A total of 10 randomized controlled trials (688 patients) were included. Meta-analysis showed a significantly shorter time to flatus (t/h) (MD, −9.45; 95% CI, −10.76 to −8.13; p < 0.00001), a shorter length of hospital stay (t/d) (MD, −5.22; 95% CI, −7.46 to −2.99; p < 0.00001), and a lower incidence of postoperative complications (%) (OR, 0.14; 95% CI, 0.03–0.64; p = 0.01) in the SJZD/EN group than the EN group. Compared with the EN, the SJZD/EN group had a higher level of albumin(g/L) (MD, 2.59; 95% CI, 1.90–3.28; p < 0.00001), prealbumin (mg/L) (MD, 36.81; 95% CI, 13.41–60.20; p = 0.002), transferrin (g/L) (MD, 0.19; 95% CI, 0.10–0.28; p < 0.0001), immunoglobulin G (g/L) (MD, 2.61; 95% CI, 2.12–3.09; p < 0.00001), immunoglobulin A (g/L) (MD, 0.38; 95% CI, 0.31–0.45, p < 0.00001), immunoglobulin M (g/L) (MD, 0.31; 95% CI, 0.22–0.41; p < 0.00001), CD3+ (%) (MD, 6.73; 95% CI, 3.48–9.98; p < 0.0001), CD4+ (%) (MD, 4.32; 95% CI, 3.30–5.33; p < 0.00001), and CD4+/CD8+ (MD, 0.20; 95% CI, 0.11–0.28; p < 0.00001).
Conclusions: Sijunzi decoction combined with enteral nutrition appears to have efficacy and safety for gastric cancer.
Disclosure Statement
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Additional information
Notes on contributors
Xinrong Chen
Conceptualization: Chen Xinrong, Yang Kun; Data curation: Chen Xinrong, Yang Jie; Formal analysis: Chen Xinrong, Yang Kun; Project administration: Li Ka; Resources: Li Ka; Software: Chen Xinrong, Yang Jie; Supervision: Li Ka, Yang Kun; Writing – original draft: Chen Xinrong, Yang Jie; Writing – review & editing: Li Ka, Yang Kun.
Kun Yang
Conceptualization: Chen Xinrong, Yang Kun; Data curation: Chen Xinrong, Yang Jie; Formal analysis: Chen Xinrong, Yang Kun; Project administration: Li Ka; Resources: Li Ka; Software: Chen Xinrong, Yang Jie; Supervision: Li Ka, Yang Kun; Writing – original draft: Chen Xinrong, Yang Jie; Writing – review & editing: Li Ka, Yang Kun.
Jie Yang
Conceptualization: Chen Xinrong, Yang Kun; Data curation: Chen Xinrong, Yang Jie; Formal analysis: Chen Xinrong, Yang Kun; Project administration: Li Ka; Resources: Li Ka; Software: Chen Xinrong, Yang Jie; Supervision: Li Ka, Yang Kun; Writing – original draft: Chen Xinrong, Yang Jie; Writing – review & editing: Li Ka, Yang Kun.
Ka Li
Conceptualization: Chen Xinrong, Yang Kun; Data curation: Chen Xinrong, Yang Jie; Formal analysis: Chen Xinrong, Yang Kun; Project administration: Li Ka; Resources: Li Ka; Software: Chen Xinrong, Yang Jie; Supervision: Li Ka, Yang Kun; Writing – original draft: Chen Xinrong, Yang Jie; Writing – review & editing: Li Ka, Yang Kun.