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Abstract
Background: Zinc deficiency is reportedly common and influences prostate cancer (PCa) incidence among elderly males. Hence, this study was designed to determine the prevalence of zinc deficiency among Nigerian males with PCa.
Materials and Methods: This was a descriptive case–control study among 220 PCa patients and 220 age-matched controls. Clinical and laboratory variables were obtained and evaluated among both study groups. Analysis of serum PSA and plasma zinc was done under standard protocols.
Results: No age difference (cases: 69.73 ± 7.72 vs controls: 68.97 ± 7.32; P > 0.05) was observed among both study groups. Prevalence of zinc deficiency among PCa and control groups was 69.1% and 21.8%, respectively. Zinc deficiency was more prevalent among the elderly PCa patients (n = 119; 78.3%) compared to elderly controls. Higher proportion (n = 136; 89.5%) of zinc-deficient PCa patients presented with moderate-severe PCa disease. Elderly PCa patients (n = 119; 81.0%) predominated among those exhibiting moderate-severe PCa disease. Inverse relationship between zinc and age was more pronounced among the PCa patients (Beta= −0.454; P < 0.001) than the controls (Beta= −0.343; P ≤ 0.001).
Conclusion: The study findings indicate a significant burden of zinc deficiency associated with adverse outcome of PCa among elderly males with the disease. Zinc deficiency may serve as a therapeutic target or diagnostic marker in elderly males with PCa.
Acknowledgments
We appreciate the kind commitment of all staff of the Department of Chemical Pathology for their individual assistance during the conduct of this study.
Disclosure Statement
The authors have no conflict of interest to disclose.