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Abstract
Objectives
We aimed to evaluate the possible role of dietray TAC against different types of cancers in a systematic review and meta-analyses of observational studies. Methods: A literature search of authentic electronic resources had been performed to obtain the relevant studies up to February 2020. Results: Twenty-one studies including nine prospective and twelve case–control studies were included in the current systematic review and meta-analysis. These studies have included 1404297 individuals. Higher TAC categories were associated with 21% reduced risk of colorectal cancer, 27% reduced risk of endometrial cancer, 42% reduced risk of gastric cancer, and 32% reduced risk of pancreatic cancer. In meta-analysis of prospective studies also highest category of TAC was associated with reduced incidence of breast cancer (RR= 0.68; CI: 0.54, 0.86; P = 0.025), colon cancer (RR= 0.92; CI: 0.74, 1.16; P = 0.01), hepatocellular carcinoma (RR= 0.49; CI: 0.35, 0.69; P < 0.001), gastric cancer (RR= 0.65; CI: 0.50, 0.84; P = 0.001), lung cancer (RR= 0.90; CI: 0.85, 0.95; P = 0.001) while increased risk of rectal cancer (RR= 1.02; CI: 0.69, 1.52; P = 0.005). Conclusion: Higher intake of dietary TAC was in association with reduced risk of different types of cancers in meta-analysis of observational studies.
Disclosure Statement
The authors declate that there is no conflict of interest.
Ethical Consideration
This study was conducted according to the guidelines laid down in the Declaration of Helsinki and the protocol of the study has been approved by the ethics committee of the Tabriz University of Medical Sciences. Moreover, the ethics committee of Tabriz University of Medical Sciences has approved the study’s protocol (Registration number: IR.TBZMED.VCR.REC.1398.181).