Preoperative Nutritional Risk Index Predicts Recurrence of Oligometastatic Prostate Cancer in Patients Undergoing Cytoreductive Radical Prostatectomy

Abstract

This study aims to investigate the specific predictive role of the preoperative Nutritional Risk Index (NRI) in oligometastatic prostate cancer (OM-PC) patients, who have undergone cytoreductive radical prostatectomy (cRP), and explored its prognostic index values. A total 89 OM-PC patients, who were identified between 2013 and 2019, were included in the present study. The Kaplan-Meier method and Cox regression analysis were used to separately assess the prostate specific antigen (PSA) progression-free survival (PFS). Overall accuracy was determined by analyzing the area under the receiver operating characteristic curve (AUC). The analysis of patients in these three different groups indicated that patients with lower NRI values were significantly associated with a higher Gleason score and more neoadjuvant androgen deprivation therapy (P < 0.05). In addition, the Kaplan-Meier curve analysis revealed that OM-PC patients in the preoperative high-risk group had shorter PSA-PFS (P < 0.001). Furthermore, the multivariate analysis further predicted that the high-risk NRI value is a common independent prognostic factor for shorter PSA-PFS (P < 0.001). Moreover, it was also observed that the AUC value of the NRI score was higher than other conventional nutritional indicators. The present study suggests that NRI can potentially be used as a new prognostic indicator for PSA-PFS for patients with OM-PC after cRP.

Conflicts of Interest

The authors declare no competing interests in the present work.

Ethical Statement

The authors are accountable for all aspects of the work, ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was approved by the Ethics Committee of the Tenth People's Hospital of Shanghai (SHSY-IEC-4.1/20-22/01), and all patients provided a signed informed consent.

Contributions

(I) Conception and design: Yongzhen Liu, Yadong Guo; (II) Administrative support: Xudong Yao, Yongzhen Liu; (III) Provision of study materials or patients: Pengfei Wu, Ruiliang Wang, Wenchao Ma, Wentao Zhang; (IV) Collection and assembly of data: Ruiliang Wang, Shiyu Mao, Yuan Wu, Ji Liu; (V) Data analysis and interpretation: Pengfei Wu, Wenchao Ma, Zongtai Zheng, Junfeng Zhang; (VI) Manuscript writing: Yongzhen Liu, Yadong Guo; (VII) Final approval of manuscript: All authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by the Shanghai Science and Technology Commission (grant number: 19411967700).