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Nutrition and Cancer Volume 73, 2021 - Issue 8
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Research Article

Pomegranate (Punica granatum) Fruit Extract Suppresses Cancer Progression and Tumor Angiogenesis of Pancreatic and Colon Cancer in Chick Chorioallantoic Membrane Model

Thangirala Sudhaa Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USAORCID Iconhttps://orcid.org/0000-0002-6428-1804View further author information
ORCID Icon,
Deena S. Mousab Yale University, New Haven, Connecticut, USAORCID Iconhttps://orcid.org/0000-0002-9294-015XView further author information
ORCID Icon,
Ali H. El-Farc Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, EgyptORCID Iconhttps://orcid.org/0000-0001-9721-4360View further author information
ORCID Icon &
Shaker A. Mousaa Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USACorrespondence[email protected]
View further author information
Pages 1350-1356 | Received 05 Dec 2019, Accepted 06 Jul 2020, Published online: 06 Aug 2020
 
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Abstract

Pomegranate fruit extract contains many polyphenols and flavonoids of diverse biological importance including anticancer potential. In cancer, the angiogenesis process facilitates solid cancer growth and metastasis. Here, the antiangiogenic effect of pomegranate fruit extract against human pancreatic cancer (Suit-2) and colon (colo205) cell lines in the chick chorioallantoic membrane (CAM) model was studied along with the effect of pomegranate fruit extract on fibroblast growth factor (FGF2). Pomegranate fruit extract significantly reduced the tumor weight and hemoglobin content in CAM models of pancreatic Suit-2 and colon colo205.

Disclosure Statement

The authors declare no conflict of interest.

Additional information

Funding

This study was funded by the Pharmaceutical Research Institute (PRI) and its Center of Excellence for Translation Research (CETR).

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