Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study

Abstract

Meningioma is associated with the development of vasogenic edema defined as disrupted blood brain barrier. Vitamin D3 through its own nuclear receptor can regulate the expression of many effective agents on the integrity of the blood brain barrier. This study aimed to investigate the association between preoperative serum levels of 25(OH)D and peritumoral brain edema in patients with meningioma. One hundred and twelve patients with meningioma completed the study. Serum 25(OH)D levels assessment and magnetic resonance imaging (MRI) were done for all patients at the beginning of the study. The percentage of edema index (EI) was used to estimate the extent of peritumoral brain edema through preoperative MRI. The median serum level of 25(OH)D in the patients with the percentage of EI < 100% was significantly higher than those with > 100% (65.58 vs. 37.33, P < 0.001). The median percentage of EI was 24.9. Preoperative serum levels of 25(OH)D had an inverse and significant correlation with the percentage of EI as by increasing each 1 ng/mL of serum 25(OH)D, EI was decreased approximately 4% (95% CI; −5.984 to −1.952, P < 0.001). Vitamin D may be a protective factor for peritumoral brain edema of meningioma.

Author’s Contribution

The authors’ contributions are as follows: M.H, M.S. and Z.V. conceptualized and designed the study; M.H. and Z.V. analyzed data; M.H. wrote the manuscript; M.H, M.S. and A.Z. collected data; M.H. and M.S. interpreted the data; A.Z. provided professional comments; Z.V. critically revised the manuscript for intellectual content and data accuracy; M.H. and M.S. had responsibility for final content. All of the authors read and approved the final manuscript.

Acknowledgments

We convey our gratitude to the National Nutrition and Food Technology Research Institute, Tehran, Iran, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Functional Neurosurgery Research Center and the neurosurgery ward staff of Shohada Tajrish Hospital.

Disclosure statement

The authors declare that there are no conflicts of interest.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.