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Abstract
Angiogenesis is a complex physiological process that cannot be treated with single agent therapy. Several edible fungi have been known to encompass bioactive compounds, and are promising sources of multi-component drugs. One such widely consumed edible fungi is Cantharellus cibarius, which has been explored for its biological activities. The present study focused on assessing the anti-angiogenic activity of petroleum ether and ethanol extracts of C. cibarius using chick chorioallantoic membrane (CAM) assay. Both the extracts showed a dose-dependent response which was compared with the anti-angiogenic activity of the positive controls silibinin, and lenalidomide. The extracts were also studied for their lipoxygenase (LOX) inhibitory potential and compared to ascorbic acid as the positive control. The IC50 values of the petroleum ether extract, ethanol extract, and ascorbic acid for LOX inhibition assay were 135.4, 113.1, and 41.5 µg/mL, respectively. Although both the extracts showed similar responses in CAM assay, ethanol extract proved to be more potent in LOX inhibition assay. Finally, the extracts were investigated for their chemical composition using GC-MS. A correlation between LOX inhibition and anti-angiogenic potential was established at the molecular level. A meticulous literature search was carried out to correlate the biochemical composition of the extracts to their anti-angiogenic activity.
Disclosure Statement
The authors have no conflict of interest
Author Contribution
Sandesh J. Marathe conceived and designed the study. Sandesh J. Marathe and Wahiba Hamzi performed the CAM and LOX inhibition assay. Tuulikki Seppänen-Laakso performed the GC-MS analysis. Sandesh J. Marathe performed the statistical analysis. Salem Shamekh and Jan Deska secured funding for the project. Salem Shamekh, Abdulla M. Bashein and Rekha S. Singhal supervised the study and provided guidance. All authors reviewed, edited and approved the final version of the manuscript.