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Abstract
The aims of this study were to assess the presence of dysgeusia in patients receiving anticancer therapy and to explore possible factors influencing its occurrence. A total of 242 adult patients with histological diagnoses of malignant neoplasia and undergoing all types of anticancer treatment were included in the analysis. Data were collected from May 2019 to November 2019 at the Unit of Medical Oncology of Careggi University Hospital, Florence, Italy. Dysgeusia was assessed using the Chemotherapy-induced Taste Alteration Scale (CiTAS), while treatment-related symptoms were assessed using the Common Terminology Criteria for Adverse Events (CTCAE). Patients were aged 68 ± 13 years, mostly males (65%). A large proportion of them was undergoing chemotherapy (42.2%), while the others were receiving immunotherapy (20.7%), hormone therapy (15.5%), targeted therapy (12.8%), or a combination of them. Overall, 21.5% of patients reported dysgeusia, 17.4% nausea, 10.7% dysosmia, 9.9% xerostomia, 4.5% mucositis, and only 3.7% vomiting. The targeted therapy showed the greatest adverse effects, followed by chemotherapy, immunotherapy, and hormone therapy. When patients with dysgeusia were analyzed, phantogeusia and parageusia was the most affected dimension of gustatory disorders. Significant differences (p < 0.05) in CiTAS scores were found according to treatment-related symptoms for nausea and mucositis.
Funding
None
Disclosure of Interest
No potential competing interest was reported by the authors.
Guarantor of the Paper
Jaclyn Di Meglio
Author Contributions
Jaclyn Di Meglio: Conceptualization, Methodology, Data Curation, Formal analysis, Investigation, Writing - Original Draft. Monica Dinu: Formal analysis, Writing - Original Draft. Laura Doni: Conceptualization, Methodology, Data Curation, Investigation, Project administration. Gemma Rossi: Investigation. Roberta Giorgione: Investigation. Barbara Colombini: Writing - Original Draft, Supervision. Lorenzo Antonuzzo: Conceptualization, Methodology, Writing - Review & Editing, Supervision, Project administration. Francesco Sofi: Conceptualization, Methodology, Formal analysis, Writing - Review & Editing.