https://orcid.org/0000-0002-8250-7475
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Abstract
Background
Accumulating evidence has suggested that Fibroblast growth factor 21 (FGF21) plays an important role in metabolic diseases. This study aimed to investigate the relationship between plasma FGF21 levels and body composition parameters in gastric cancer (GC) patients.
Methods
This study was cross-sectional based on a prospective cohort of GC patients in a single center. Computer tomography (CT) and bioelectrical impedance analysis (BIA) were used to estimate skeletal muscle and adipose tissue mass. Blood samples were collected and plasma concentrations of FGF21 were measured by ELISA. Spearman’s rank correlation test and logistic regression analysis were performed to assess associations between plasma FGF21 levels and these body composition parameters.
Results
A total of 66 GC patients were enrolled in this study. Plasma FGF21 levels were significantly higher in women compared with men. The plasma FGF21 levels were positively correlated with fat mass index (FMI), fat mass percentage (FM%), and subcutaneous adipose tissue index (SATI). Furthermore, after adjustment for confounders, the lower plasma FGF21 levels were remain associated with increased odds for low SATI.
Conclusions
Plasma FGF21 levels were positively associated with FMI, FM%, and SATI in GC patients, suggesting a potential mechanistic link between FGF21 and subcutaneous adipose tissue in GC.
Disclosure of Interest
The authors have no conflicts of interest to declare.
Author Contributions
YJ.Z and JC.Y contributed to the conception and design of the research; YJ.Z, L.J, and PF.S contributed to the acquisition and analysis of the data; ZQ.M, WM.K, X.Y, and YQ.L contributed to the interpretation of the data; YJ.Z drafted the manuscript. All authors critically revised the manuscript, agree to be fully accountable for ensuring the integrity and accuracy of the work, and read and approved the final manuscript.