Abstract
Purpose
To evaluate changes in cone functions using light-adapted (LA) 30 Hz flicker and LA 3.0 electroretinography (ERG) in intravitreal ranibizumab (IVR)-treated naïve neovascular age-related macular degeneration (nAMD) patients.
Materials and methods
This retrospective interventional study reviewed the medical records of 32 nAMD patients (32 eyes) who received monthly IVR between January 2019 and January 2021. A comprehensive ophthalmic examination, including best-corrected visual acuity (BCVA) testing and slit-lamp biomicroscopy, was performed as part of their clinical care, followed by LA 30 Hz flicker and LA 3.0 ERGs, optical coherence tomography, and fundus fluorescein angiography. All measurements were taken before IVR (baseline), as well as at months 6 and 12 later. Treatment was resumed for up to 12 months if recurrence occurred.
Results
Compared to baseline, visual acuity improved significantly at months 6 and 12, respectively, coinciding with a significant decrease in central macular thickness (p < 0.05 for all). LA 30 Hz flicker ERG b-wave amplitude decreased significantly between baseline and months 6 and 12, respectively (p < 0.05 for both). There were no significant changes in LA 3.0 ERG a- and b-wave amplitudes between baseline and month 6 (p > 0.05 for both), but a significant decrease existed between baseline and month 12 (p < 0.05 for both). While LA 3.0 ERG a-wave implicit time increased significantly (p < 0.05 for both) between baseline and months 6 and 12, respectively, b-wave implicit time did not (p > 0.05 for both). Also, LA 30 Hz flicker ERG b-wave implicit times did not differ significantly between baseline and months 6 and 12, respectively (p > 0.05, for both).
Conclusions
IVR was associated with long-term electrophysiological changes in cone functions, as measured by LA 30 Hz flicker and LA 3.0 ERGs.
Ethical approval
This single-centered retrospective interventional study abided by the ethical standards of the Helsinki Declaration and obtained full approval from the Institutional Review Boards of the Batman Training and Research Hospital Ethics Committee (Approval ID: 2021-284), which included a review of patient medical records from the hospital database between January 2019 and January 2021.
Author contributions
Both ZB and HHG contributed significantly to the conception and design of the current study, acquisition, analysis and interpretation of the data, the drafting and essential revision of the manuscript for relevant intellectual content and the endorsement of the final version of the manuscript. ZB = Zeki Baysal; and HHG = Hamidu Hamisi Gobeka.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
Data are available from the corresponding author on reasonable request.