![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Objective
We sought to evaluate the accuracy of periostin for the diagnosis of asthma through a systematic review and meta-analysis.
Methods
we searched the electronic databases (PubMed, EMBASE, Web of science) to find relevant studies through December 31, 2018. Studies selecting, data extraction and quality assessment were conducted by two researchers independently according to inclusion and exclusion criteria. We used bivariate mixed effects model to conduct the meta-analysis.
Results
A total of 9 studies including 1448 subjects with asthma were analyzed. The pooled sensitivity, specificity, diagnostic odds ratio (DOR) were 0.68 (95% CI, 0.42–0.86), 0.87 (95% CI, 0.76–0.93) and 13.78 (95% CI, 4.64–40.93) respectively. The area under the summary receiver operating curves (SROC) was 0.87 (95% CI, 0.84–0.90). The Spearman correlation coefficient indicated that no threshold effect existed in the included studies. The study design had statistical significance for sensitivity results (p < 0.001) through regression analysis. Heterogeneity might be caused by non-threshold effect.
Conclusion
Periostin has moderate accuracy in the diagnosis of asthma.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.