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Diagnosis

Assessment of pediatric asthma exacerbation with the use of new PROMIS measures

, BS, , , PhD, , MS, , PhD, , MD, , MD, MS & , MSPH , MD show all
Pages 1298-1306 | Received 11 Mar 2020, Accepted 17 Jun 2020, Published online: 09 Jul 2020
 

Abstract

Objective

Patient reported outcome measures, such as the Patient Reported Outcomes Measurement Information System (PROMIS) may be used to assess patient functioning for asthma and aid in understanding the impact of asthma exacerbation. These domains may be utilized as endpoints in clinical trials and to guide clinical care. The purpose of this study was to determine psychometric properties of the new PROMIS measures for children with asthma, at baseline and with exacerbation.

Methods

We conducted a cross-sectional analysis of children with acute asthma exacerbation or at baseline health. Psychometric properties of validity (using known groups and correlation) and reliability (using Cronbach’s alpha and IRT) for the new PROMIS measures were determined.

Results

Our study included 220 subjects, 102 were enrolled during an acute exacerbated state. Cronbach’s alpha and IRT reliability was greater or equal to 0.75. Our subjects experiencing an acute exacerbated state reported worse T-scores for pain related domains: pain behavior 45.7 vs 53.5 (p < 0.001), pain quality sensory 44.4 vs 48.5 (p < 0.005), pain quality affective 42.5 vs 51.3 (p < 0.001), and physical stress experience 60.5 vs 65.4 (p < 0.001); and asthma impact 47.9 vs 61.0 (p < 0.001), than subjects at baseline. Child and parent-proxy agreement ranged from 35% to 56%.

Conclusions

The new Pediatric PROMIS domains are valid and reliable for use in children with asthma, for both child-reported and parent-proxy reported outcomes. It was determined that children with acute asthma exacerbation have worse patient reported outcomes (PROs) for the new pain related domains and asthma impact.

Declaration of interest

Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 1U19AR069519. The project described was also supported in part by the National Center for Advancing Translational Sciences, National Institutes of Health, Award Number UL1TR001436. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Additional information

Funding

This work is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number 1U19AR069519-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The project described was also supported in part by the National Center for Advancing Translational Sciences, National Institutes of Health, Award Number UL1TR001436.

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