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Pediatric Asthma

Association between Helicobacter pylori and risk of childhood asthma: a meta-analysis of 18 observational studies

, MD, , MD & , MDORCID Icon
Pages 890-900 | Received 26 Oct 2020, Accepted 15 Feb 2021, Published online: 08 Mar 2021
 

Abstract

Objective: The association between Helicobacter pylori (H. pylori) and childhood asthma is unclear. Thus, the aim of this study was to explore the association between H. pylori and childhood asthma.

Methods: A literature search, study selection, and data extraction were performed independently and in duplicate. Data were analyzed using STATA software.

Results: Eighteen studies enrolling 17,196 children were analyzed. All studies were of moderate-to-high quality. Four studies subcategorized H. pylori infection according to CagA status. Overall, there was a significant negative association between H. pylori and risk for childhood asthma (OR = 0.68; 95% CI, 0.54–0.87; P = 0.002), with no/marginal publication bias identified by the Egger’s test and the Begg’s test (P = 0.162 and P = 0.198, respectively). The observed inverse association persisted for CagA(+) strains of H. pylori (OR = 0.58; 95% CI, 0.35–0.96; P = 0.034) but not for CagA(−) strains (OR = 0.52; 95% CI, 0.12–2.28; P = 0.387). There was no significant difference between studies with respect to study design, participant age, geographical region, and method of measuring H. pylori.

Conclusion: The evidence suggests that H. pylori infection, particularly CagA(+) H. pylori infection, is inversely associated with the risk of childhood asthma.

Supplemental data for this article can be accessed at publisher’s website.

Disclosure statement

The authors declare that they do not have a conflict of interest.

Ethics approval

Not applicable. This was a review of the literature.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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