Longitudinal assessment of loss and gain of lung function in childhood asthma

Abstract

Objective

The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV₁ in asthmatic children participating in out-of-hospital follow-up.

Methods

A total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV₁ (percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV₁.

Results

The median (25^th; 75^th percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV₁ variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function.

Conclusion

Better initial FEV₁ value and less FEV₁ variability are associated with loss of lung function or reduced lung growth in asthmatic children.

Keywords:

• Spirometry
• forced expiratory volume in 1 s
• lung function variability

Declaration of interest

The authors have no competing interests to declare. The authors alone are responsible for the content and writing of this article.

Funding

The author(s) reported there is no funding associated with the work featured in this article.