An electrochemical study of Atenolol using Patton and Reeder’s modified pencil graphite electrode as an electrochemical sensor

ABSTRACT

An electrochemical sensor has been developed using Patton and Reeder’s reagent which is electropolymerised on pencil graphite electrode (PR-PGE) for the selective and sensitive determination of Atenolol (ATN). The cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectra were used to check the analytical applicability of the proposed sensor for the investigation of ATN. To achieve better electrochemical response, the parameters such as pH, scan rate and electron transfer kinetics were determined. Under optimum experimental conditions, the linear calibration curve shows concentration linear range of 0.1–1.8 µM and the limit of detection 4.9 × 10⁻⁸ M. The proposed sensor shows better selectivity towards the determination of ATN in presence of organic and inorganic interfering species. The analytical performance of the PR-PGE has been studied successfully by determining ATN present in the pharmaceutical sample.

KEYWORDS:

• Atenolol
• cyclic voltammetry
• differential pulse voltammetry
• electrochemical impedance spectroscopy

Acknowledgments

The authors are grateful to the University Grant Commission, New Delhi for providing UGC-BSR fellowship (Order No. F, 25-1/2013-14(BSR) 7-229/2009) and SERB, New Delhi for providing instrumentation facility.

Disclosure statement

No potential conflict of interest was reported by the authors.