The efficiency of PCL/HAp electrospun nanofibers in bone regeneration: a review

Abstract

Electrospinning is a method which produces various nanofiber scaffolds for different tissues was attractive for researchers. Nanofiber scaffolds could be made from several biomaterials and polymers. Quality and virtues of final scaffolds depend on used biomaterials (even about single substance, the origin is effective), additives (such as some molecules, ions, drugs, and inorganic materials), electrospinning parameter (voltage, injection speed, temperature, …), etc. In addition to its benefits, which makes it more attractive is the possibility of modifications. Common biomaterials in bone tissue engineering such as poly-caprolactone (PCL), hydroxyapatite (HAp), and their important features, electrospinning nanofibers were widely studied. Related investigations indicate the critical role of even small parameters (like the concentration of PCL or HAp) in final product properties. These changes also, cause deference in cell proliferation, adhesion, differentiation, and in vivo repair process. In this review was focussed on PCL/HAp based nanofibers and additives that researchers used for scaffold improvement. Then, reviewing properties of gained nanofibers, their effect on cell behaviour, and finally, their valency in bone tissue engineering studies (in vitro and in vivo).

Keywords:

• Nanofiber
• poly-caprolactone
• hydroxyapatite
• bone tissue engineering

Acknowledgments

This paper is related to a PhD thesis by Behnaz Banimohamad-Shotorbani with the supervisory of Dr. Hajar Shafei. The thesis is funding by Tabriz University of Medical Sciences [thesis No: 64739 and ethical number: IR.TBZMED.VCR.REC.1399.055].

Disclosure statement

No potential conflict of interest was reported by the author(s).