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Hemoglobin
international journal for hemoglobin research
Volume 46, 2022 - Issue 6
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Brief Reports

Use of Capillary Electrophoresis Migration Position for the Presumptive Identification of Hemoglobin Variants Prevalent in China

Miao Xua Department of Laboratory Medicine, Weifang People’s Hospital, Weifang, Shandong Province, People’s Republic of ChinaView further author information
,
Ming-Yang Lib Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaView further author information
,
Yu Zengb Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaView further author information
,
Weijie Xieb Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaView further author information
,
An-Ping Xub Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9827-7272View further author information
ORCID Icon &
Ling Jib Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 330-334 | Received 18 Aug 2022, Accepted 14 Oct 2022, Published online: 25 Jan 2023
 
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Abstract

Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

This study was supported by Weifang Health Committee Foundation [WFWSJK-2021–204] and Guangdong Medical Science Foundation [B2021064].

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