A novel multi-stimuli-responsive theranostic nanomedicine based on Fe₃O₄@Au nanoparticles against cancer

Abstract

A novel multi-stimuli-responsive theranostic nanomedicine was designed and fabricated by the conjugation of a thiol end-capped poly(N-isopropylacrylamide-block-acrylic acid) (HS-PNIPAAm-b-PAA) onto Fe₃O₄@Au nanoparticles (NPs) followed by physical loading of doxorubicin hydrochloride (Dox) as a general anticancer drug. For this purpose, Fe₃O₄@Au NPs were fabricated through small Au nanolayer grown on larger magnetic NPs. A HS-PNIPAAm-b-PAA was synthesized through an atom transfer radical polymerization (ATRP) approach, and then conjugated with as-synthesized Fe₃O₄@Au NPs by Au-S bonding. The Dox loading capacity of the synthesized Fe₃O₄@Au/Polymer theranostic NPs was calculated to be 81%. The theranostic nanomedicine exhibited excellent in vitro drug release behavior under pH and thermal stimuli. The anticancer activity evaluation using MTT assay (against MCF7 cells) revealed that the fabricated Fe₃O₄@Au/Polymer has high potential as theranostic nanomedicine for cancer therapy of solid tumors. This nanosystem can also applied in photothermal therapy, hyperthermia therapy, and their combination with chemotherapy due to presence of gold and Fe₃O₄ nanomaterials in its structure.

Keywords:

• Cancer
• chemotherapy
• theranostic nanomedicine
• Fe₃O₄@Au nanoparticles
• stimuli-responsive

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

The authors gratefully acknowledge the partial financial support from Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran [Grant Number: 980305], and Payame Noor University, Tehran, Iran.