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Cancer Investigation Volume 38, 2020 - Issue 4
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Articles

The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer

Jun Satoa Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; View further author information
,
Hideaki Karasawaa Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0358-3398View further author information
ORCID Icon,
Takashi Suzukib Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
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Shun Nakayamaa Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; ;b Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
,
Munetoshi Katagiria Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; ;b Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, JapanView further author information
,
Shimpei Maedaa Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; View further author information
,
Shinobu Ohnumaa Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; View further author information
,
Fuyuhiko Motoia Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; View further author information
,
Takeshi Naitoha Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; View further author information
&
Michiaki Unnoa Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; View further author information
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Pages 214-227 | Received 18 Aug 2019, Accepted 08 Mar 2020, Published online: 19 Mar 2020
 
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Abstract

Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and MAPK signaling pathways in vitro, and decreased tumor growth and lymph node metastasis in vivo. Cripto-1 could be a useful prognostic biomarker and therapeutic target in colorectal cancer.

Disclosure statement

The authors have no conflict of interest to declare.

Additional information

Funding

This work was supported by JSPS KAKENHI Grant Number JP25893013 and JP15K19867.

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