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Research Article

Akt Phosphorylation Orchestrates T11TS Mediated Cell Cycle Arrest in Glioma Cells

, , , , , , ORCID Icon & show all
Pages 854-870 | Received 09 May 2021, Accepted 22 Sep 2021, Published online: 11 Oct 2021
 

Abstract

The novel anti-neoplastic glycopeptide T11TS retards glioma both in in-vitro clinical samples and in-vivo models. This study investigates the correlation between altering the glioma microenvironment with glioma arrest and death. Flow cytometry, immunoblotting, ELISA, and co-immunoprecipitation were employed to investigate glioma cell arrest and death. Results include a decline in phosphorylation of Akt and attenuation of p21 phosphorylation (Thr145,Ser146) and disassociation of p-Akt-Mdm2 and p-Akt-BAD facilitating death by Akt>BAD. T11TS influence phosphorylation patterns in two focal axes Akt>p21 and Akt>Mdm2>p53. The current article provides crucial insight in deciphering the mechanism of T11TS induced glioma cell arrest and death.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Funding

Council of Scientific and Industrial Research (CSIR), Govt. of India, [Sanction No. (0152)/06/EMR-II] provided funding for the study.

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