Application in Gene Editing in Ovarian Cancer Therapy

Abstract

The onset and progression of ovarian cancer (OC) are closely related to dysregulated gene expression. Current treatments for OC are mainly limited to surgery and chemotherapy. However, due to low drug sensitivity, the prognosis OC is exceptionally poor and the recurrence rate remains high. Hence, it is vital to develop new treatment strategies. Gene editing for site-specific genomic modification is a powerful novel tool for the treatment of OC. In this article, current gene editing research for the treatment of OC is reviewed to provide a reference for the clinical application of new approaches to improve treatment outcomes and prognosis.

Keywords:

• Gene editing
• ovarian cancer
• drug sensitivity

Acknowledgments

We thank International Science Editing (http://www.internationalscienceediting.com) for editing this manuscript.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Funding

his work was supported by grants from The Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT310013], Foundation Project of Guizhou Provincial Administration of Traditional Chinese Medicine [QZYYXG-2020-10], Doctor of Guizhou Medical University starts the fund [XBHJ [2020] 018]. Science and Technology Plan Project of Baiyun District [BKHT[2019] No. 43]. The central government guide local science and technology development projects [QKZYD[2019]4008].