International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Abstract

In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3–5) had a higher frequency of perineural invasion and higher tumor volumes (>50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

Keywords:

• Prostatic adenocarcinoma
• grade groups
• gleason score
• perineural invasion
• extraprostatic extension
• cancer-specific survival

Acknowledgements

The authors would like to thank all the staff members of the Department of Histopathology, Liaquat National Hospital and Medical College for their assistance and cooperation in conducting this study.

Disclosure statement

No potential conflict of interest was reported by the author(s).