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Critical Reviews in Biotechnology Volume 41, 2021 - Issue 1
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Review Articles

Nitrilase: a promising biocatalyst in industrial applications for green chemistry

Ji-Dong Shena Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China;b Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
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Xue Caia Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China;b Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
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Zhi-Qiang Liua Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China;b Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou, P.R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3259-6796View further author information
ORCID Icon &
Yu-Guo Zhenga Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China;b Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
Pages 72-93 | Received 06 Jan 2020, Accepted 16 Aug 2020, Published online: 12 Oct 2020
 
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Abstract

Nitrilases are widely distributed in nature and are able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. In industry, nitrilases have been used as green biocatalysts for the production of high value-added products. To date, biocatalysts are considered to be important alternatives to chemical catalysts due to increasing environmental problems and resource scarcity. This review provides an overview of recent advances of nitrilases in aspects of distribution, enzyme screening, molecular structure and catalytic mechanism, protein engineering, and their potential applications in industry.

Disclosure statement

The authors report no declarations of interest.

Additional information

Funding

The authors gratefully acknowledge the financial supports from the National Natural Science Foundation of China (No. 21476210), Natural Science Foundation of Zhejiang Province (No. R3110155 and Z4090612) and Public Welfare Technology Applied Research Projects of Zhejiang Province (2014C33223).

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