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Abstract
| Abbreviations | ||
| A | = | Active |
| ABNR | = | Adopted basis Newton-Raphson |
| CARDs | = | Caspase activation and recruitment domains |
| CTD | = | C-terminal domain |
| dsRNA | = | Double-stranded RNA |
| HEL1 | = | Helicase1 |
| HEL2 | = | Helicase2 |
| HEL2i | = | Helicase2 insertion |
| MD | = | Molecular dynamics |
| NA | = | Inactive |
| P | = | Pincer |
| PDB | = | protein data bank |
| PME | = | Particle mesh Ewald |
| RIG-I | = | Retinoic acid-inducible gene-I |
| RMSD | = | Root mean square deviation |
| RMSF | = | Root mean square fluctuation |
| SD | = | Steepest descent |
| TI | = | Thermodynamic Integration |
Communicated by Ramaswamy H. Sarma
Acknowledgement
AK thank MHRD, Govt. of. India for funding. We acknowledge support from the Science and Engineering Research Board (SERB, Govt of India), IIT Guwahati. Biomolecular Simulation Lab (BSL), Bioinformatics Facility (BIF) and PARAM-ISHAN of IIT Guwahati is gratefully acknowledged for providing the computing facility.
Disclosure statement
The authors declare no conflict of interest.