A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment

Abstract

Heterocyclic derivatives have more interesting biological properties which hold a remarkable place in pharmaceutical industries due to their unique physiochemical properties and ease of adaption in various biological environments. Of many, the above-said derivatives have been recently examined for their promising action against a few malignancies. Specifically, anti-cancer research has benefited from these derivatives’ natural flexibility and dynamic core scaffold. In any case, concerning some other promising anti-cancer drugs, heterocyclic derivative doesn’t come without deficiencies. To be a successful drug candidate it should poses Absorption, Distribution, Metabolism and Eliminations (ADME) parameter, and must also have good binding interaction towards carrier protein as well as DNA and less in toxic nature, economically feasible. In this review, we described the overview of biologically important heterocyclic derivatives and their main application in medicine. Further, we focus types of biophysical techniques to understand the binding interaction mechanism.

Communicated by Ramaswamy H. Sarma

Keywords:

• Heterocyclic derivatives
• protein/DNA-drug interaction
• fluorescence spectroscopy
• computational studies

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors thank VIT for providing ‘VIT RGEMS SEED GRANT’ for carrying out this research work. S.C. was supported by a Grant-in-Aid for Early-Career Scientists fund (KAKENHI No.22K15249) by Japan Society for the Promotion of Science.