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Journal of Biomolecular Structure and Dynamics Volume 41, 2023 - Issue 24
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Research Articles

Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents

G. O. Nascimentoa Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, BrazilCorrespondence[email protected]
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S. P. D. Marquesb Departamento de Química, Instituto Federal de Educação, Ciência e Tecnologia do Ceará, Quixadá, CE, BrazilView further author information
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C. E. G. Maiaa Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, BrazilView further author information
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A. F. de Sousaa Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, BrazilView further author information
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R. L. Cunhac Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Belo Horizonte, MG, BrazilView further author information
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M. R. Maltac Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Belo Horizonte, MG, BrazilView further author information
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R. W. Owena Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, BrazilView further author information
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M. K. A. Ferreirad Postgraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil;e Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, BrazilView further author information
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A. W. da Silvaf Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil;e Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, BrazilView further author information
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E. L. Rebouçasf Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, BrazilView further author information
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J. E. S. A. de Menezese Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, BrazilView further author information
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M. M. Marinhog Group of Theoretical Chemistry and Electrochemistry(GQTE), State University of Ceará, Limoeiro do Norte, CE, BrazilView further author information
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E. S. Marinhog Group of Theoretical Chemistry and Electrochemistry(GQTE), State University of Ceará, Limoeiro do Norte, CE, BrazilView further author information
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H. S. dos Santosh Center for Exact Sciences and Technology, Vale do Acarau State University, Sobral, CE, BrazilORCID Iconhttps://orcid.org/0000-0001-5527-164XView further author information
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A. S. M. C. Salibai Luiz de Queiroz College of Agriculture, Piracicaba, SP, BrazilView further author information
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A. P. Massariolii Luiz de Queiroz College of Agriculture, Piracicaba, SP, BrazilView further author information
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S. M. Alencari Luiz de Queiroz College of Agriculture, Piracicaba, SP, BrazilView further author information
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A. G. O. Sartorii Luiz de Queiroz College of Agriculture, Piracicaba, SP, BrazilView further author information
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M. T. S. Trevisana Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil;i Luiz de Queiroz College of Agriculture, Piracicaba, SP, BrazilView further author information
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Pages 14871-14886 | Received 07 Nov 2022, Accepted 18 Feb 2023, Published online: 16 Mar 2023
 
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Abstract

The present study focused on investigating the antioxidant, antiglycation activity, digestive enzymes inhibition, bioaccessibility and hypoglycemic effect of C. arabica leaves extracts. The extracts deactivated the O2•-, ROO•, H2O2, HOCl reactive oxygen species. Coffee leaves showed strong inhibition of α-glucosidase (IC50 = 40.30 μg mL−1) greater than the isolated metabolites and acarbose. There was also inhibition of pancreatic lipase (IC50 = 56.43 μg mL−1) in addition to a hypoglycemic effect in zebrafish similar to acarbose and metformin. With the exception of rutin, all biocompounds were detected at all stages of in vitro digestion. Finally, these results suggest that C. arabica leaf extracts possess antidiabetic and anti-obesity properties that can be attributed to the main metabolites and the synergistic action between them.

Communicated by Ramaswamy H. Sarma

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors are grateful to Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (Funcap) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for financial support through the project CAPES/PROEX process: 88887.372227/2019-00.

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