Epstein-Barr virus infection status among first year undergraduate university students

Abstract

Objective

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which disproportionately affects university students. This population has the potential to benefit from a prophylactic EBV vaccine trial. Our objectives were to determine EBV infection status and associated demographic/lifestyle factors among first year undergraduate university students at the beginning and end of first year.

Methods

EBV infection status was assessed by testing for circulating IgG class antibodies against EBV viral capsid antigen.

Results

Of 198 starting students; 56.1% were positive for EBV antibodies with a higher rate in women (64.8%) than male (41.1%); p = 0.002. A history of deep kissing was associated with a higher rate of EBV antibody positivity. On follow-up 8 months later at the end of freshman year, 22.4% had acquired EBV antibodies for a primary infection incidence of 33.6/100 person years.

Conclusion

These findings indicate that our first year undergraduate population contains sufficient EBV-naïve subjects for a prophylactic vaccine trial.

Keywords:

• EBV antibody
• EBV seroprevalence
• Epstein-Barr virus
• immunity
• university first year students

Additional information

Funding

This work was supported in part by the University of Iowa Clinical and Translational Science Award granted with funds from the National Institutes of Health (grant number UL1TR002537).