Antibody Testing in Atypical Optic Neuritis

ABSTRACT

Optic neuritis (ON) is a common manifestation of central nervous system demyelinating disorders such as multiple sclerosis (MS). The last two decades have seen increasing recognition of atypical optic neuritis syndromes, driven in large part by characterization of demyelinating diseases associated with antibodies to aquaporin 4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG). Given their increased importance in the workup of ON, familiarity with serological tests for ON has become essential for ophthalmologists. This review will discuss technological aspects, performance, and clinical implications of serological tests for atypical ON.

KEYWORDS:

• Atypical optic neuritis
• neuromyelitis optica spectrum disorder
• CRMP-5 antibody
• aquaporin-4 antibody
• MOG antibody

DISCLOSURE STATEMENT

Melanie Truong-Le and Bartek Chwalisz each declare no potential conflicts of interest.

HUMAN AND ANIMAL RIGHTS AND INFORMED CONSENT

This article does not contain any studies with human or animal subjects performed by any of the authors.