Polymorphisms in COMT, ADRB2 and HTR1A genes are associated with temporomandibular disorders in individuals with other arthralgias

ABSTRACT

Objective: To evaluate the association between polymorphisms in genes and comorbid presence of arthralgias and TMD.

Methods: This is a case-control study. The groups formed were individuals with chronic arthralgia and 1) myofascial pain (n = 42); 2) articular (n = 16); 3) multiple diagnoses (n = 69); 4) with TMD and without some other arthralgia (n = 16); 5) without TMD but with pain in other joints (n = 82); and 6) a control group (n = 72). SNPs in COMT, ADRB2, and HTR1A genes were investigated.

Results: The CT genotype for the COMT (rs9332377) gene was associated with the absence of myofascial pain (p = .05). In the ADRB2 (rs1042713) gene, the AA genotype was associated with the absence of myofascial pain (p = .03).

Discussion: This study supports the hypothesis that alterations in the COMT, ADRB2, and HTR1A genes influence the presence of chronic pain and TMD.

KEYWORDS:

• Temporomandibular joint dysfunction syndrome
• arthralgia
• polymorphism genetic
• chronic pain
• osteoarthritis

Acknowledgments

The authors are indebted to all the patients who enthusiastically agreed to be part of this project and gratefully acknowledge the assistance of the Department of Oral Biology at the University of Pittsburgh and unit of clinical research of the University Hospital Antônio Pedro.

Conflict of interest

All authors disclose no actual or potential conflict of interest including any financial, personal, or other relationships with other people or organizations that could inappropriately influence (bias) their work. All authors state that there are no competing interests.

Additional information

Funding

Financial support of this work was provided by School of Medicine of Petropolis [001/2016].