182
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Research on the Effects of Levetiracetam in Spinal Cord Injury Model in Rats: An Experimental Study

, MD, , MD, , MDORCID Icon, , MD, , MD & , MD
Pages 252-262 | Published online: 11 Sep 2018
 

Abstract

Purpose: Despite advances in spinal biomechanic research, surgical techniques, and rehabilitation processes, no significant improvement has been identified in the treatment of spinal cord injury (SCI) and neurological recovery. Aim of the Study: This study was designed to investigate the potential therapeutic effects of methylprednisolone and levetiracetam on SCI. Materials and Methods: In this study, 42 male Wistar Albino rats, each weighing 300–350 g, were separated into three main groups: control group, acute and subacute stage groups. With the exception of the control group, a T7-8 dorsal laminectomy was performed on the spinal column of the rats. A temporary vascular aneurysm clip was then applied to the spinal cord for 1 min to create SCI and methylprednisolone or levetiracetam was administered intraperitoneally to all except the control and SHAM control groups. The damaged spinal cord was removed for histopathological and biochemical examinations. Results: Both pharmacological agents were determined to have improved the histopathological architecture in damaged neural tissues during the acute period of SCI, but could not sustain this activity in the subacute period. Neither pharmacological agent affected the biochemical data in the acute nor subacute stages. Conclusions: Both pharmacological agents showed histopathological healing effects in injured tissues during the acute phase of SCI in this rat model but these effects could not be sustained in the subacute period. No effect on biochemical data was seen in either the acute or subacute period. There is a need for further advanced studies to determine the effects of levetiracetam on the healing processes in SCI.

This article refers to:
Research on the Effects of Levetirasetam in Spinal Cord Injury Model

Acknowledgments

The authors would like to thank Erkan Kaya and Emir Kuscu for their valuable assistance in this study.

DISCLOSURE STATEMENT

The authors report no conflict of interest. The authors are responsible for the content and writing of the paper.

FUNDING

This thesis study was financially supported by Kırıkkale University Scientific Research Project (BAP) Coordination Unit (Project Number: 2016/102).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access
  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart
* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.