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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 35, 2022 - Issue 5
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Case Studies

Sarcoidosis-associated renal AA amyloidosis and crescentic necrotizing glomerulonephritis

Albert Buia Department of Internal Medicine, Mayo Clinic, Jacksonville, FloridaORCID Iconhttps://orcid.org/0000-0002-2927-7885
, DO, PharmDORCID Icon,
Cherise Corteseb Department of Pathology, Mayo Clinic, Jacksonville, FloridaORCID Iconhttps://orcid.org/0000-0001-7307-6565
, MDORCID Icon &
Nabeel Aslamc Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, FloridaCorrespondenceaslam.nabeel.mayo.edu
ORCID Iconhttps://orcid.org/0000-0003-2735-0951
, MDORCID Icon
Pages 680-682 | Received 13 Jan 2022, Accepted 25 Apr 2022, Published online: 16 May 2022
 
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Abstract

Sarcoidosis has a rare and independent association with renal AA amyloidosis and crescentic necrotizing glomerulonephritis. However, coexisting entities in sarcoidosis have not been previously described. Herein, we report a 66-year-old Caucasian woman who presented with generalized fatigue, weight loss, and acute kidney injury in the setting of likely sarcoidosis. Renal biopsy revealed AA amyloid fibrils with fibrocellular crescents. The patient’s clinical symptoms and laboratory results improved with high-dose glucocorticoids and azathioprine.

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