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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 35, 2022 - Issue 5
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Case Studies

Squamous cell carcinoma arising in an epidermal inclusion cyst

Suzanne Alkula Department of Dermatology, Baylor College of Medicine, Houston, TexasCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0166-5368
, MDORCID Icon,
Christopher N. Nguyenb Baylor College of Medicine, Houston, Texas
, MD,
Nisha S. Ramanic Department of Pathology, Michael E. DeBakey VA Medical Center, Houston, Texas
, MD,
Mahmud Alkuld School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TexasORCID Iconhttps://orcid.org/0000-0002-7746-2495
, BSORCID Icon,
Ida Orengoa Department of Dermatology, Baylor College of Medicine, Houston, Texas
, MD,
Ikue Shimizue Department of Dermatology, Michael E. DeBakey VA Medical Center, Houston, Texas
, MD &
Bhuvaneswari Krishnanb Baylor College of Medicine, Houston, Texas;c Department of Pathology, Michael E. DeBakey VA Medical Center, Houston, Texas
, MD show all
Pages 688-690 | Received 20 Apr 2022, Accepted 09 May 2022, Published online: 23 May 2022
 
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Abstract

Squamous cell carcinoma (SCC) arising from an epidermal inclusion cyst (EIC) is uncommon. We present a case of a 70-year-old man with a scalp nodule with persistent discharge that was resected based on the clinical impression of an EIC. Histopathologic exam showed an infundibular EIC with an epidermal type of squamous epithelium; however, some of the cyst lining and lumen was replaced by squamous proliferation with malignant features. There are 56 cases of SCC arising in EICs reported in the English literature. Though suspected EICs are commonly benign, a thorough pathologic evaluation is required to rule out malignancy.

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