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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 35, 2022 - Issue 6
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Case Studies

Azacitidine-induced myopericarditis in acute myeloid leukemia

Mahmoud Ismayla Department of Internal Medicine, Creighton University School of Medicine, Omaha, NebraskaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9033-7835
, MDORCID Icon,
Asmini KCb Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska
, MD,
Abhishek Thandrac Division of Cardiovascular Medicine, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska
, MD,
Nattapong Sricharoenc Division of Cardiovascular Medicine, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska
, MD &
Amy Arounic Division of Cardiovascular Medicine, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska
, MD
Pages 849-851 | Received 23 Jun 2022, Accepted 04 Aug 2022, Published online: 18 Aug 2022
 
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Abstract

Hypomethylating agents are commonly used in the treatment of myelodysplastic syndromes and are known to cause bone marrow suppression; however, cardiac complications are rare. We describe a patient who was diagnosed with acute myeloid leukemia and developed myopericarditis after receiving chemotherapy with azacitidine. Our case highlights the importance of a thorough history, including medication review, in patients with suspected myopericarditis. It also raises awareness about the potential cardiac side effects of azacitidine.

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