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Journal of Biomaterials Science, Polymer Edition Volume 32, 2021 - Issue 15
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Research Article

Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels

Chenshu WangJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. ChinaView further author information
,
Lijuan WangJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. ChinaView further author information
,
Xiuzhen WanJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. ChinaView further author information
,
Xuefeng JiangJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. ChinaView further author information
&
Jiang YuanJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4788-1787View further author information
ORCID Icon
Pages 1998-2008 | Received 11 May 2021, Accepted 03 Jul 2021, Published online: 28 Jul 2021
 
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Abstract

A biocompatible hydrogel is ideal for tissue engineering and regeneration. In this study, methacrylated keratin (KerMA) was synthesized for the first time and then blended with poly(ethylene glycol dimethacrylate) (PEGDMA) to form hydrogel through photocrosslinking. The chemical structure, gelation time, swelling behavior, hydrophilicity, cytotoxicity, and 3D printability of PEGDMA/KerMA hydrogels were characterized and exploited. The PEGDMA/KerMA hydrogels performed good cytocompatibility, providing potential applications for tissue engineering and regenerative medicine.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Jiangsu Higher Education Institutions [19KJA310001 and PAPD].

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