Ultra-Widefield Fluorescein Angiography in Intermediate Uveitis

ABSTRACT

Purpose: To examine associations between pattern of vascular leakage on ultrawide-field fluorescein angiography (UWFFA) and visual acuity, cystoid macular edema (CME), and inflammatory activity in intermediate uveitis.

Methods: Single center cross-sectional, retrospective review of medical records, spectral domain optical coherence tomography (SD-OCT) and angiographic images of intermediate uveitis patients who underwent UWFFA over a 12-month period.

Results: Forty-one eyes from 24 patients were included. Twelve eyes (29%) exhibited peripheral leakage, 26 eyes (64%) had diffuse leakage and three eyes (7%) had no leakage. Diffuse leakage was associated with 0.2 logMAR worse visual acuity than peripheral leakage (p = 0.02). There was no statistically significant difference in the odds of having CME when diffuse leakage was compared to peripheral leakage.

Conclusion: UWFFA identifies retinal vascular pathology in intermediate uveitis not present on clinical examination. Diffuse retinal vascular leakage was associated with worse visual acuity when compared to peripheral and no leakage patterns.

Keywords:

• intermediate uveitis
• retinal vasculitis
• Ultra-widefiedl fluorescein angiography

This article is referred to by:

In Response to Laovirojjanakul W., Acharya N. and Gonzales J. A.’s “Ultra-Widefield Fluorescein Angiography in Intermediate Uveitis”

ACKNOWLEDGMENTS

We wish to thank Erica Browne, MS for statistical analysis.

DECLARATION OF INTEREST

Drs. Gonzales and Acharya are provided with device and imaging support by Optos, Inc. All authors are responsible for the content and writing of the article.

FUNDING

This work was supported by the National Eye Institute [NEI K23EY026998, EY02162]. The Department of Ophthalmology at UCSF is supported by a core grant from the National Eye Institute, EY02162, and an unrestricted grant from Research to Prevent Blindness, New York, NY. The F.I. Proctor Foundation received a temporary loan equipment loan for the study from Optos, plc (Dunfermline, Fife, Scotland, UK). Optos had no oversight in the design, conduct or publication of current research. None of the authors have any financial interest in Optos, plc.

Additional information

Funding

This work was supported by the National Eye Institute [NEI K23EY026998, EY02162]. The Department of Ophthalmology at UCSF is supported by a core grant from the National Eye Institute, EY02162, and an unrestricted grant from Research to Prevent Blindness, New York, NY. The F.I. Proctor Foundation received a temporary loan equipment loan for the study from Optos, plc (Dunfermline, Fife, Scotland, UK). Optos had no oversight in the design, conduct or publication of current research. None of the authors have any financial interest in Optos, plc.